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I fell in love with this bike the first time I saw it. Took it out for a spin and it was like night and day when compared to my previous road bike. My first bike was built with speed and racing in mind, but I would feel the consequences on longer rides. This isn't the case with the Domane! This bike is VERY comfortable. The ISOspeed in the seat tube really makes a difference. The only draw back to Domane is it's SLIGHTLY heavier than the Madone (not by much though, maybe 150g-200g), but it makes up for that in comfort. That being said, I have no problem averaging 22mph on this bike, and feel comfortable the entire time. The 4.3 is a great value as it comes with almost full 105's, making shifting fast and flawless. Two thumbs up!